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Phrixotoxin-2 / PaTx2
簡(jiǎn)要描述：Smartox Biotechnology是*一家專門生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：PHX002-50010- 廠商性質(zhì)：代理商
- 更新時(shí)間：2025-10-25
- 訪 問(wèn) 量：2454
產(chǎn)品介紹
Phrixotoxin-2 / PaTx2
Blocker of Kv4.2 and Kv4.3 channels(鉀離子通道Kv4.2 和Kv4.3阻斷劑)
Phrixotoxin-2 (PaTx2) has been isolated originally from the venom of the Chile fire tarantula Phrixotrichus auratus. Phrixotoxin-2 is a 31 amino acid peptide that contains three disulphide bridges. Phrixotoxin-2 specifically blocks recombinant Kv4.2 and Kv4.3 currents with IC50 values of 34 nM and 71 nM, respectively. It does so by altering the gating properties of the channels. The inhibition of Kv4.2 and Kv4.3 currents is fully reversible upon washout. Kv4.1 is only slightly sensitive to Phrixotoxin-2 (maximal block of 20 by 300 nM). Kv1, Kv2 and Kv3 channel subfamilies are insensitive to this toxin.
Phrixotoxin-2 技術(shù)資料
氨基酸序列：Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Glu-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Leu-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Arg-Ile-Ile-Asn-Met-NH2
二硫鍵：Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25
長(zhǎng)度 (aa)： 31
分子式： C169H259N49O43S8
分子量： 3921.71 Da
外觀：white lyophilized solid
可溶性：water or saline buffer
CAS 號(hào)：221889-63-0
來(lái)源：Synthetic
純度：> 98%
產(chǎn)品信息
PHX002-50010 | Phrixotoxin-2 | 5 x 0.01mg |
PHX002-00100 | Phrixotoxin-2 | 0.1mg |
PHX002-00500 | Phrixotoxin-2 | 0.5mg |
PHX002-01000 | Phrixotoxin-2 | 1mg |
